Effectiveness of elective single versus double frozen embryo transfer in good prognosis IVF patients

Objective: This study aimed to evaluate the effectiveness of elective single embryo transfer (eSET) versus double (DET) in frozen cycles following vitro fertilization (IVF) treatment good prognosis patients. The outcome would provide medical data for multiple pregnancy rate reduction IVF treatment.
 Methods: multicenter retrospective cohort was performed patients undergoing first (FET) at centers which belonged IVFMD Group, Vietnam, from January 2018 May 2020. Patients were divided into four groups, based on number embryos transferred, as follows: Group 1: one quality day-3 (eSET D3), 2: day-5 D5), 3: two (DET and 4: D5). primary live birth rates (LBR) after FET. Secondary outcomes also analyzed, including (?-hCG positive, clinical pregnancy, miscarriage < 12 weeks, ongoing 20 [MBR]), well neonatal (birth weight gestational age birth).
 Results: There 819 patients, FET 132 eSET D3, 278 D5, 140 DET 269 D5. LBR MBR values significantly lower D3 group than (LBR: 22.7% vs 39.3%, p = 0.002; MBR: 3.3% 29.1%, 0.001, respectively). D5 compared with (9.6% 38.3%, 0.001), while comparable between groups (41.4% 42.8%, 0.74). Birth similar DET, regardless or transfer.
 Conclusions: Among infertile, women FET, decreased transfer, still sustaining an acceptable outcomes.